ABSTRACT
Introduction: Coadministration of drugs with synergistic effects considered one of the methods to increase the effectivenessof analgesia. The aim of this study is to evaluate the efficacy of midazolam to potentiate the analgesic effect of fentanyl as anadjuvant to bupivacaine.Materials and Methods: This is a hospital based prospective, randomized, double-blind interventional control study conductedat SMS medical college and hospitals, Jaipur. A total of 90 patients were enrolled in the study. They were allocated into threegroups, 30 in each. A total of 3.7 ml study drugs injected in each group. Intraoperative monitoring of hemodynamic parameters,duration of surgery, onset of sensory and motor block, duration of analgesia, sensory and motor block, and incidence of adverseeffects was done and compared.Results: There was no significant difference in mean pulse rate, systolic blood pressure, diastolic blood pressure, and meanarterial pressure (P > 0.05). The mean duration of surgery in Group A, B, and C was 101.3 ± 13.08, 92.93 ± 15.28, and 95.93± 16.03 min, respectively (P > 0.05). The mean onset time of sensory block in Group A was 7.29 ± 1.23, in B 4.92 ± 0.60, andin C 4.79 ± 0.91 min (P < 0.05). The mean onset time of motor block in Group A was 8.75 ± 0.55, in B 7.79 ± 0.42, and in C7.57 ± 0.29 min. In Group A, mean time of sensory block was 194.4 ± 6.80, in B 236.60 ± 12.79, and in C 254.30 ± 7.32 min. InGroup A, mean duration of motor block was 180.2 ± 5.22, in B 188.7 ± 4.04 and in C 199.6±6.69 min. In Group A, mean durationof analgesia was 215.7 ± 14.6, in B 445.8 ± 18.92, and in C 522.3 ± 16.33 min. The incidence of adverse effects was insignificant.Conclusion: We conclude that midazolam potentiates the effect of fentanyl in terms of prolonged duration of analgesia andprolonged motor and sensory block when used as an adjuvant of bupivacaine without any significant hemodynamic compromise.